منابع مشابه
Integrins in cell migration.
Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as traction sites. This includes signaling com...
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Integrins are a family of heterodimeric receptors that bind to components of the extracellular matrix and influence cellular processes as varied as proliferation and migration. These effects are achieved by tight spatiotemporal control over intracellular signalling pathways, including those that mediate cytoskeletal reorganisation. The ability of integrins to bind to ligands is governed by inte...
متن کاملIntegrins in cell migration--the actin connection.
The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell...
متن کاملFibronectin and integrins in cell adhesion and migration.
Introduction Fibronectin, other cell-adhesion molecules, and their integrin receptors appear to play important roles in cell migration during embryonic development, tumour-cell invasion and metastasis, and wound healing (reviewd in [ 11). Recent studies have defined critical peptide-recognition regions in fibronectin that are required for its interactions with cell-surface receptors. For exampl...
متن کاملIntegrins control migration style
anen et al. (page 515) show that  1 and  3 integrins direct different types of motility, despite binding fibro-nectin with similar efficiencies. Cells expressing  1 integrin move in a random manner, whereas cells with  3 integrin expression move in a persistent fashion. The proteins control cell migration by altering the activities of the Rho GTPases RhoA and Rac, which in turn control thre...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2011
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a005074